In the spring when cherry blossoms are flying, Kafuka Fuka, a girl on her way to school, found a man hanging from a cherry tree. She hurriedly rescued the man, but was asked a strange question, "What if he is really dead?!" Facing this extremely negative man, the optimistic Kafuka gave a nonsensical explanation, "The person who hanged himself just wanted to grow taller," and called the man by his nickname "Pink Minister." Kafuka Fuka left the man and went to the classroom, only to find that the man she had just met was the new teacher at the school, Nozomi Itoshiki. Nozomi, who is called "Teacher Despair" by students because the Chinese characters for "despair" together, has a catchphrase of "I am desperate! I am desperate for the world of xx." His hilarious school life with 32 students in the second-year class began.