During the Three Kingdoms period, wars broke out. Young Hua Tuo treated the people in his hometown of Bozhou and lived a free and easy life. Hua Tuo's magic hands brought Mingxin, the daughter of the prefect, back to life, and earned the reputation of a miracle doctor. From then on, he and Mingxin had an indissoluble bond. In order to develop Ma Fei San to treat Mingxin's eyes, Hua Tuo began to travel and look for medicine. In the capital, Hua Tuo had many encounters with the hero Guan Yu, the treacherous hero Cao Cao, and his senior brother Wu Side, and witnessed the sinister officialdom and the coldness of the world. What hurt Hua Tuo the most was that his beloved girl Mingxin was tragically occupied by Wu Side. In the mountains of Dongwu, the desperate Hua Tuo was instructed by a hermit, and he suddenly woke up and determined to become a great doctor who healed people, hearts, and the country. The Battle of Chibi, scraping bones to treat poison, and adventures in secret places. No matter how windy and rainy it was, he never changed his innocent heart to save the people. The successful development of Mafeisan also brought Hua Tuo and Mingxin's love to fruition. However, when happiness came, Cao Cao grabbed Hua Tuo due to illness, suspicion, and hatred, and the great doctor who practiced medicine to save the world and brought back the dead died in prison.