Full-time housewife Claire (Julie Bowen) and her real estate agent husband Phil (Ty Burrell) raise two teenage daughters and a ten-year-old son. Claire's sixty-year-old father Jay (Ed O'Neill) has just married a young and beautiful wife Gloria (Sofía Vergara), and together with Gloria's ten-year-old son from her ex-husband, they form a new family of three. Claire's younger brother Mitchell (Jesse Tyler Ferguson) and his gay lover Cameron (Eric Stonestreet) have just adopted a baby girl from Vietnam and are eager to be a good father. These three families have their own troubles to face and solve, and their frequent interactions have also caused some unpleasantness. When problems continue to arise before them, how do they resolve conflicts and maintain family harmony and joy?