In the 33rd year of Tianqing, the two imperial doctors, Li and Song, were ordered by Emperor Tianqing to go through hardships to find the magic medicine "in vain", but unexpectedly caused a disaster. The two families also had a deep hatred because of a misunderstanding of stealing medicine. Many years later, Li Shi, the descendant of the genius doctor Li Kuo, became a down-and-out veterinarian. He never thought that he would become famous in the market for successfully saving lives in Hehuan Tower. At the same time, Song Ruxue, the descendant of the enemy, changed his name and hid beside Li Shi, waiting for an opportunity to murder him, but was accidentally injured. In the process of getting along and caring for each other, the two fell in love with each other. Holding the medicine-seeking diary left by his predecessors, Li Shi and his third uncle Li Yifeng and Song Ruxue embarked on the road of searching for the long-lost magic medicine "in vain". The three of them had their own little thoughts and encountered many embarrassing things along the way. As the truth about the identities of Meng Fan, the top woman of Hehuan Tower, and Yingchunhua, the female shopkeeper, was revealed, Emperor Tianqing unexpectedly came back to life, and the mysteries of the year were finally revealed one by one...