James Wolk plays Jackson Oz, a young and rebellious American zoologist who has lived in Africa for many years and serves as a travel guide for tourists. When he travels in the wilderness of Africa, he finds that animals show strange aggressive behaviors. Soon, the animals' aggressive behaviors become more terrifying, more cunning, and more organized. He recalls the controversial theory his father said before his death: animals may threaten human survival. There is a certain correlation between his father's theory and the facts he has seen with his own eyes, and he has reason to suspect that there is a huge conspiracy behind the whole thing. He must solve the real cause of this strange symptom pandemic as soon as possible, otherwise humans will soon have nowhere to hide.