At the end of the 22nd century, an unknown alien creature called "Gamiras" by humans occupied Mars and continued to launch planetary bombs with strong radioactive materials to the earth, causing countless casualties on the earth, and was on the verge of extinction, and was forced to go underground to survive. At this critical juncture, humans formed a space fleet to expedition to Mars, but almost all of them were wiped out. The Yamato, which escaped by chance, became the last hope of mankind. At the same time, a mysterious device fell to the earth across the Milky Way. After testing, it was found that the device could actually eliminate radioactive substances. In order to seek help from the owner of the device, the highly intelligent creatures of Iskandar Star in the Magellanic Cloud, humans decided to go all out and send the Yamato on this expedition. Gu Guojin (Takuya Kimura), a former member of the space fleet who lost his brother in the battle of Mars, was called back to the team and became a member of the great historical moment with a group of friends. And Gamiras, who learned of the human movement, also launched a wave of deadly attacks... This film is adapted from the original work of the same name by Leiji Matsumoto.