Recently, a serial murder case has occurred. The most disgusting thing is that the murderer cuts the victim's throat after each crime. FBI agent Will (Edward Norton) is responsible for the investigation of this case. After a detailed investigation, Will analyzes that this person cuts the victim's throat and eats it every time, but he can't find any clues of the murderer. Will seeks help from Hannibal (Anthony Hopkins), a criminal psychologist with mental illness, hoping that Hannibal can portray the criminal's criminal psychology to help solve the case. Unexpectedly, Hannibal has a mental illness and intends to hurt Will. In the end, he was imprisoned in a mental prison, and the case was left unresolved. Many years later, Will encountered the same murder case again. Although the suspect has been identified, if Will wants to clearly figure out this person's criminal psychology and take advantage of him, he has to find Hannibal again.