Although the body of "Jigsaw" John Kramer (Tobin Bell) is dead, his spirit lives on. This time, William Easton (Peter Outerbridge), the boss of a medical insurance company, becomes his target of hunting and testing. William is greedy and cunning. He invented a set of medical insurance calculation formulas. At the same time, with the help of his minions, he successfully denied insurance to countless terminally ill people and made dirty money from it. However, he did not expect that one day he would have to hand over the decision-making power of his life to others. He must follow the rules of the game of "Jigsaw" and carefully find a way to escape. On the other hand, Mark Hoffman (Costas Mandylor), one of John's disciples, successfully killed police officer Strong and tried to draw the police's attention to Strong. However, various signs have long made his peers doubt Mark's identity. His identity is about to be exposed, and his violent path that violates John's spirit is slowly coming to an end...