In the second season, Tom Riley plays Leonardo da Vinci, who is trying to save Florence from the conspiracy and rebellion of the Sappazzi family and Lorenzo, who is seriously injured. Leonardo da Vinci will challenge the limits of his body and mind to defend Florence from the invasion of Roman forces. At the same time, the Medici family will face an incredible new round of threats, and Leonardo da Vinci will continue his mission to find the Book of Leaves and uncover the unknown truth about his mother's past history. Leonardo da Vinci soon realizes that what awaits him is a deadly mission challenge - an enemy stronger than the Pope of Sis! His exploration will take him to foreign countries and re-evaluate his understanding of the world and his evaluation of his past.