Mia (Tiffany Haddish) and Mel (Rose Byrne) have known each other for a lifetime. They regard each other as their lifelong friends and jointly open a cosmetics company, hoping to help each other and reach the peak of their lives. However, the business world is not so easy to get into. After several setbacks, the two girls not only have to bear heavy debts, but also face the danger of the company going bankrupt at any time. Claire (Salma Hayek) is a notorious blood sucker in the cosmetics industry. She proposed to buy their company. Although the acquisition has indeed alleviated Mia and Mel's economic crisis, it has also brought unprecedented tests to their friendship.