In 2018, the war between Skynet and humanity plunged the world into an apocalyptic situation. John Connor (Christian Bale), the spiritual leader of the resistance army, led a mission and gained new ideas to defeat Skynet. Skynet timely launched a new target ranking, with Connor in second place, and Connor's young father Kyle Reese at the top. At the same time, Marcus (Sam Worthington), a strong man who has forgotten his past experience, appears in the ruins of Los Angeles. He meets by chance with Reese, a rebel fighter, and teamed up to resist The headquarters was attacked by a robot on the way, and Reese was captured. Marcus, who was alone, was led by the female fighter Blair of the resistance army to have a fateful encounter with Connor. However, the conflict between man and machine forced Connor to regard each other as enemies... Reese's life or death in the Skynet Center was uncertain. At the same time, the top leaders of the resistance army were unwilling to postpone the forced attack plan. Connor no longer had much time, and he could only choose to carry out an infiltration operation that would gamble his life and honor.