The so-called "Shirobako" refers to videotapes specially made and given to the staff involved in the animation production before the animation is broadcast. It has a long and touching history. Because these videotapes are usually packed in white boxes, they are called "Shirobako". The producer Aoi Miyamori (voiced by Juri Kimura) who has always adhered to her ideals, the serious but somewhat cowardly original artist Ema Yasuhara (voiced by Haruka Kamura), the voice actor Shizuka Sakaki (voiced by Haruka Chikan) who feels that she is not appreciated, the CG artist Misa Fujido (voiced by Asami Kono) and the scriptwriter Midori Imai (voiced by Hitomi Owada) who is easily obsessed with her own interests and hobbies, five girls with different personalities, work together to successfully complete Shirobako's dream. What interesting stories will happen on this not-so-easy road?