Kuroshu Academy is a famous boarding school, which is divided into the general department and the night department. The staff of the night department are all elite students, and they all have super beautiful appearances. But in fact, the students of the night department have a special identity: vampires! And this identity cannot be known to the students of the general department. The adopted daughter of the chairman Kuroshu Huiyan and the general department student Kuroshu Yuuki and the childhood sweetheart Kiryu Zero guard this academy and deal with the troubles that arise when human students come into contact with vampires. In Zero's heart, he hates vampires because his family was killed by vampires four years ago, and only Zero survived miraculously. And Yuki has a good impression of the noble vampire Kuran Shu who once saved her life. Surrounding Yuki's mysterious life experience, the inner struggle of Zero as a vampire hunter and the contradiction of his desire for blood and his special physique, the special care of the pure-blood senior Shu for Yuki and his hatred for Zero, how will the delicate relationship between the three develop? "Vampire Knight" is adapted from the girls' manga of the same name drawn by cartoonist Hino Matsushita.