After experiencing unimaginable pain and torture, Sydney Prescott (Neve Campbell), a survivor of the University of Windsor murder case in Westbourne, now lives in seclusion in the mountains, providing psychological counseling to women in crisis over the phone. At the same time, her deeds were adapted into a series of horror movies "Stab", and the protagonist of the third "Stab", Carton, was killed on the street. This incident reunited Sydney, David (David Arquette) and Gail (Courteney Cox). The ghost face killer is still haunting, triggering a new round of bloody massacres in Hollywood... This film is the third in the "Scream" series, and won the 2000 Youth Choice Award for the most chemical combination (Courteney Cox & David Arquette), the 2001 Hot Entertainment Award for Best Actor (David Arquette) and Best Actress (Neve Campbell).