Alice (Milla Jovovich) returns to Tokyo to seek revenge on Umbrella, which is hiding at the bottom of the earth. Wesker (Shawn Roberts) implements self-righteous safety and technical standards. Alice breaks into the restricted area and goes straight to Huanglong. And Wesker is willing to destroy the city to fight a trapped beast. In the end, when he escapes in a helicopter, he is coerced by Alice. In a hurry, he injects Alice with an immune virus to T cells, which makes her lose her superpowers and can only fly over the uninhabited Alaska. There has been no sign of life on Earth for 177 days. However, Alice accidentally discovers Claire (Ali Larter). They follow the Arcadia signal and return to the city of hell, where zombies are shocking. They are greeted by survivors who also heard the signal. With the help of the mysterious prisoner Chris (Wentworth Miller), they head for the Arcadia ship...