The rampage at Shimada School completely destroyed the idea of coexistence between humans and parasitic beasts. Izumi Shinichi (Shota Sometani)'s life has undergone a huge change, and he and Satomi (Ai Hashimoto) seem to have a rift because of this incident. On the other hand, Tamiya Yoshiko (Eri Fukatsu)'s mood gradually changed after giving birth to a child. She tried to make her companions integrate into the human world in a peaceful way, but Tofuku City Mayor Hirokawa Tsuyoshi (Ikki Kitamura) instructed Goto (Tadanobu Asano) and other diehards among the parasitic beasts to eliminate Shinichi, Koyou (voiced by Abe Takashi) and freelance journalist Kuramori (Minami Omori) who tried to expose the existence of parasitic beasts. The battle between the two sides gradually escalated, and the fully armed police began to attack the city government where Hirokawa was entrenched, and Shinichi and Yoshiko will once again face a huge test of life... This film is adapted from the classic manga by Iwaaki Hitoshi, which has a cumulative circulation of more than 13 million copies.