The unknown pianist Andy (Matthias Schweighöfer) and Benno (Florian David Fitz), who has never done anything serious and is idle all day, meet in the ward. Both of them suffer from incurable terminal illnesses and have little time left. At Benno's instigation, Andy decides to escape from the ward with him and take a trip to Africa full of sunshine and passion. They have to enjoy a vigorous and unscrupulous life to the fullest before they can accept the end of death. In this way, the two "desperate men" embarked on their journey. Along the way, the crazy two created countless troubles and jokes, and their poor health also made them repeatedly pass by death. In the end, when they arrived at their destination, what kind of scene would be waiting for them?