In the previous episode, Alice (Milla Jovovich) rescued her frozen companions, but they were killed by the mercenaries who came when they left. The T virus caused the Red Queen (Megan Charpentier) to have an error in her program, and she became cruel and bloodthirsty and wanted to kill the last human and destroy the earth. Alice is the only one who can stop the Red Queen. At this moment, Alice, who has lost her ability, is imprisoned in a secret base on the seabed by the Umbrella Company. Wesker (Shawn Roberts) invaded the Umbrella Company's system through the virus. He let Alice go and told her that she was the last hope of mankind, and in order to save mankind, they must put aside their past grudges and fight against stronger enemies together. Alice met Ada Wong (Li Bingbing), a former employee of the Umbrella Company, and the two fought bravely along the way and forged a deep friendship. At the same time, Alice's old comrades-in-arms also formed a small team to break out from the outside to the inside. The Umbrella Corporation built a realistic simulated city on the seabed and used clones as experimental subjects for the T virus. In order to reach the exit, Alice and her crew must travel through four cities: Tokyo, New York, Washington and Moscow. In each city, there are zombies of its own ready to move.