Tokyo Girl's Guide is adapted from the four-frame comic of the same name serialized in Tokyo Calendar. The TV version is directed by Yuki Tanada of Million Dollar Girl. Asami Mizukawa will play the growth process of the heroine Aya from her 20s to her 40s. Aya came from her hometown to work and live in Tokyo. As she grows older and her living environment changes, her life is always facing new challenges. The drama was filmed in many landmark locations such as Ebisu and Ginza, showing a real Tokyo in all aspects.