Three years after the theft in Las Vegas, the leisurely life of Danny (George Clooney) and Tess (Julia Roberts) who have reconciled comes to an abrupt end, because the casino tycoon Benedict (Andy Garcia) suddenly finds Danny and his ten accomplices and limits them to raise money within two weeks to repay the 160 million stolen from him, including principal and interest. Ross (Brad Pitt), Linus (Matt Damon) and others gather together. They have no choice but to go to Europe to commit crimes because they are unable to repay. However, Danny and others' trip to Europe is full of difficulties. The French thief "Night Fox" (Vincent Cassel) is secretly obstructing them, and Ross's former detective girlfriend Isabelle (Catherine Zeta-Jones) leads the police to closely monitor them. This time, can Danny's gang still get away smoothly?