An unexpected incident in his childhood separated Peter Parker (Andrew Garfield) from his parents. In a blink of an eye, Peter became a high school student. He accidentally found his father's briefcase and got a clue from his uncle Ben (Martin Sheen), so he set off to visit his father's former partner at Oscorp, Dr. Kurt Connors (Rhys Ifans). Peter, who was looking for clues in the company, was accidentally bitten by a spider, and his body changed strangely on the way back. Under the guidance of Dr. Connors, Peter continued to understand and discover the extraordinary abilities in his body, joys, sorrows, and all kinds of unexpected things quickly hit him. Until one day, he became the far-reaching super warrior Spider-Man. And the vicious lizard man also appeared in the city, and Peter's extraordinary life began...