Hong Wengang (Louis Koo), the mastermind of the human organ trafficking group, suffers from a serious heart disease. In order to survive, he even plans to remove the heart of his younger brother Hong Wenbiao (Kung Suk Leung). In order to complete the undercover work, Zhijie (Wu Jing), who is addicted to drugs, follows the boss to the dock to hijack Hong Wenbiao who is trying to escape. His boss sees his uncle Chen Guohua (Simon Yam) and leads a team to the scene after receiving the tip-off, and the three parties immediately engage in a fierce exchange of fire. Zhijie, who escaped by chance, was sent to a prison in Thailand, and the warden (Zhang Jin) who controls the prison here has a thousand connections with Hong Wengang. Prison guard Achai (Tony Jaa), whose daughter suffers from leukemia, has many doubts about Zhijie's true identity, and then he accidentally discovers the terrible secret in the prison. In order to rescue his nephew, Chen Guohua traveled thousands of miles to Thailand. Hong Wengang is still struggling to death, and he eventually falls into madness...