A CIA agent Billy Pope (Ryan Reynolds) who knew state secrets died unexpectedly. With the help of Dr. Franks (Tommy Lee Jones), his memory and skills were implanted into an extremely dangerous and unpredictable criminal Jericho Stewart (Kevin Costner). Agent Greg Wells (Gary Oldman) must rely on this time bomb to destroy the criminal organization that attempts to seize state secrets. In order to save the wife and children of Billy Pope, who he gradually fell in love with after the brain transplant, and to regain his life, Jericho Stewart had to fight a desperate battle with the criminal organization within 48 hours.