Li Shizhen (played by Lin Wenlong) is free and indulging in herbal research. He is engaged to a woman named Wu Murong (played by Li Shiyun), but he can't help falling in love with the kind and beautiful Adong (played by Ye Xuan). Li Shizhen decides to keep this feeling in his heart and confess his feelings to Adong after the imperial examination. However, he not only fails to confess his feelings, but also marries Wu Murong. Li Shizhen finds that the medical books in the world today are full of errors and loopholes, so he has the idea of compiling the "Compendium of Materia Medica". However, because of his overly straightforward personality, he offends the powerful and has to temporarily interrupt the compilation of the medical book, and embarks on a journey of escape with his life in danger. Fortunately, Pang Xian (played by Ma Guoming) from the Imperial Hospital helps and supports him all the way, and Li Shizhen finally completes the masterpiece "Compendium of Materia Medica".