Hellboy (David Harbour) was originally a monster summoned by the Nazis as a biological weapon, but fortunately he was rescued and helped by Professor Bloom (Ian McShane). Under the professor's teaching and training, Hellboy gradually grew up, and then joined the Supernatural Investigation and Defense Bureau, becoming the ace fighter of the bureau. One day, the witch Blood Queen (Milla Jovovich), who had been suppressed for a thousand years, broke through the containment. In order to retaliate against mankind, she summoned a group of terrible monsters from hell and captured London. The only one who has the ability to fight against the Blood Queen is Hellboy. With the help of the psychic girl Alice (Sasha Lane) and Colonel Ben (Kim Dae-hyun), a difficult and protracted battle begins.