The lovely little girl Riley (voiced by Kaitlyn Dias) was born in an ordinary family in Minnesota. She grew up under the care of her parents and kept countless beautiful and sweet memories in her mind. Of course, these memories are also closely related to several partners that Riley has never met. They are the five main emotions of human beings: Lele (voiced by Amy Poehler), Sadness (voiced by Phyllis Smith), Fear (voiced by Bill Hader), Disgust (voiced by Mindy Kaling) and Anger (voiced by Lewis Black). As the leader of the team, Lele and other partners are committed to creating more beautiful and precious memories for the little master. One day, Riley moved to San Francisco with her parents. The dirty and cramped apartment, the unfamiliar campus environment, and the gradually lost friendship made Riley at a loss. Her negative emotions gradually accumulated, and the beautiful world in her heart gradually collapsed. In order to protect all this, Lele had to take action...