John Backaway (Owen Wilson) and Jeremy Gray (Vince Vaughn) are real wedding crashers. Not only do they like to attend weddings and enjoy themselves at various wedding parties, they also seduce young and beautiful girls at weddings. Then they disappear without a trace at the end of the wedding. This time they pretended to be businessmen and came to the wedding party of the eldest daughter of the Secretary of the Treasury, William Cleary (Christopher Walken). However, as if it was a joke of fate, John fell in love with the bridesmaid Claire (Rachel McAdams) at first sight. He tried hard to persuade Jeremy to break the routine and go to the minister's estate to spend the weekend with him. There, Jeremy's feelings for the minister's youngest daughter Gloria (Ella Fisher) gradually changed from playing to true love. However, just when the two playboys were about to turn over a new leaf, the storm started again... Can the two cynical wedding crashers get the true love of their loved ones?