Dr. House and his team of carefully selected experts are best at diagnosing critically ill patients and dealing with mysterious and critical unknown diseases. Only the most serious and unheard-of diseases will be taken over by them. They are responsible for diagnosing, judging whether it is legal, and doing their best to save the patient's life. But in this TV series, House and his team still show their optimistic and funny side, bursting out a lot of jokes.