The drama unfolds in a unit format, telling the story of the female forensic doctor "JD Song Anyan" (played by Charlene Choi) who uses her experience in the "Death Cause Decoding Institute" as a clue to help the police solve one strange case after another, while trying to find the truth of her father's old case, and a series of thrilling stories between her and the mysterious woman Lin Xiaomei (played by Gillian Chung) and the passionate detective Liu Zhiming (played by Joseph Chang). The heroine "JD Song Anyan" has a very sensitive brain due to HSP "hypersensitivity syndrome". She can't help but receive all information around the clock. While being overwhelmed by it, she also repeatedly relies on the "strongest brain" with extraordinary information reserves to open clues and solve the mystery of the unsolved case.