In order to eliminate the dissident Yang Jisheng, Yan Shifan (Law Lok-lam) of the Ming Dynasty sent his trained assassins "Thirteen Dead Zodiacs" to the Yang family to wipe out the roots. The Yang family is a martial arts family. The twelve dead zodiacs failed one after another. In the end, Yan Shifan had to send the most powerful thirteenth dead zodiac "Ren" (Qian Xiaohao) to carry out the mission. Shisheng's son Yunqing (Zhang Zhaohui) had to go to Wudang for something. No one in the Yang family could match the martial arts of "Ren", and they were tragically wiped out. When "Ren" killed the pregnant daughter-in-law of the Yang family, it was just dawn. At this moment, "Ren" changed greatly! It turned out that "Ren" could only kill people at night, and human nature would return at dawn. "Ren" killed people at the moment of sunrise, and his conscience was found out and he was in pain. He decided to betray Fan and wander around the world. Fan was afraid that "Ren" would become a future trouble, so he ordered the remaining dead zodiacs to hunt him down. Fortunately, "Ren" was helped by Qing, and was able to annihilate all the dead zodiacs. Qing even forgot the old grudge and helped "Ren" to remove the curse and return to normal. In order to repay the debt, the "man" decided to die to atone for his previous sins...