Frank (Nicolas Cage) is an emergency doctor. This race against time has put him under a lot of invisible pressure. Frank has saved many lives, but he has also watched many people die helplessly. This time, his first aid object is a girl named Rose (Cynthia Roman). Unfortunately, Rose eventually died. Rose's death brought an unprecedented huge blow to Frank. He even had hallucinations and was on the verge of mental collapse. In another rescue mission, Frank met the old man Poke (Cullen O. Johnson) and his granddaughter Mary (Patricia Arquette). Poke's serious illness made him live worse than death. With the acquiescence of Mary and Poke, Frank took the initiative to end the old man's life. For Frank, Poke's death brought relief and redemption.