Sun Yan, a biology professor at Tianfu University in Rongcheng, has lived from the Wanli period of the Ming Dynasty to the present, but has maintained an ageless face of 28 years old. While studying the secret of his immortality, naked corpses with their blood and marrow drained but without any wounds appear one after another. Sun Yan and a group of young people with special powers join hands to investigate, which leads to a family massacre that happened four hundred years ago. Sun Yan was the only survivor of this family massacre. Later it was discovered that the real culprit behind all this was Luo Zhenhai, who fell in love with Mu Xue at the same time as Sun Yan four hundred years ago. In order to find the jade pendant and Qiming water that can open the treasure of ancient Tianfu and revive the legendary Nine Infants who can change life and death and mind, Luo Zhenhai did not hesitate to shed his bloodthirsty skin to extend his life for four hundred years in an attempt to control people's hearts. However, Sun Yan met and fell in love with Luo Li four hundred years later.