Many years ago, the chimpanzee family with a fine tradition became the representative of humans sent to space to perform special missions. Today, as the third generation of the chimpanzee family, Ham III (voiced by Andy Samberg) has also been chosen as the new generation of space pilots to inherit the fine traditions of the family. The reason is that NASA's space probe worth 5.9 billion yuan suddenly disappeared in the vast galaxy. A new batch of well-trained space chimpanzee teams are needed to investigate this matter. In addition to Ham III, the space chimpanzee team also includes the brave and careful female chimpanzee Luna (voiced by Cheryl Hines) and the strong Titan (voiced by Patrick Walburton). After a hard and comprehensive training at NASA, the "three-person" team finally embarked on a mysterious journey to explore space...