Konosuke Ryoui runs a small psychiatric clinic in a back alley in the center of Shinjuku. By listening carefully to his patients and patiently facing their symptoms, Dr. Ryoui diagnoses diseases that other doctors fail to recognize, giving patients hope. Yuri Amemiya, a nurse working in the psychiatric department for the first time, becomes increasingly fascinated by psychiatric treatment by constantly observing Ryoui's work. However, Amemiya is unaware that Ryoui also has a tragic past -